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Alternatively, homoscysteine can be partitioned into the transsulfuration pathway in which two PLP-dependent enzymes, cystathionine β-synthase and cystathionine γ-lyase, catalyze the condensation of homocysteine and serine to produce cystathionine, and its subsequent cleavage to α-ketobutyrate and cysteine

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Marathon runners show higher resting levels than sedentary controls, suggesting MOTS-c may serve as a blood-based biomarker for mitochondrial fitness and endurance capacity