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Presented for research literature review only Liu Y et al

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Introduction Normal cells gain distinctive capabilities to overcome the restrictions in the tissue of origin to initiate primary tumor formation ( “The Warburg effect (aerobic glycolysis)” observed by Otto Warburg nearly a century ago is the phenomenon that cancer cells preferentially convert most glucose to lactate even in the presence of oxygen by which mitochondrial oxidative phosphorylation can proceed to generate ATP more efficiently( Prostate cancer (PCa) is unique from a metabolic perspective