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Existing dietary guidelines for Crohn’s disease and ulcerative colitis

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Hence, during Mito Cat a stalled and fragmented TCA cycle – but a highly energized mitochondria – transfers its phosphorylation potential to the cytosol where PEP metabolism via PK restricts OxPhos via ADP privation, while plasma membrane PK metabolizes PEP to increase the ATP/ADP ratio for K ATP channel closure followed by a rise in cytosolic Ca 2+ that promotes insulin secretion (Figure 2B)